Source: NHS England, NHS Scotland, Public Health Wales, Gov.uk dashboard, BBC research
Data for England is by Sustainability and Transformation Partnership area or Integrated Care System area – collaborations between the NHS and councils. For Scotland and Wales it is by health board. Comparable Northern Ireland data is not available by region. Data for England, Scotland and Wales is published weekly.
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Researchers claimed that the combination also improved progression-free survival and overall response rate.
Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.
The survival benefit demonstrates that an immune checkpoint inhibitor together with a targeted kinase inhibitor drug “is important in the first-line treatment of patients with advanced renal cell carcinoma,” said the authors of the study. The senior author is Toni Choueiri, MD, director of the Lank Center for Genitourinary Oncology at Dana-Farber.
The phase 3 CLEAR study results showed significant benefits from the combination comprised of lenvatinib, an oral kinase inhibitor that targets proteins involved in the formation of blood vessels supplying a tumor, and pembrolizumab, a